On May 15, 1864 at Resaca, Georgia, the company advanced 80 yards in front of fortifications to a natural depression. Upon unlimbering their cannons, they were immediately overrun by two Union brigades. The Cherokee Artillery fought to save their guns but they were overwhelmed. In the Atlanta Campaign they had no cannons, so their troops were parceled out to reinforce depleted companies. In December of 1864 they served in the Nashville Campaign. On April 12, 1865 the company was captured in the Battle of Salisbury, North Carolina along with the other 1,700 defenders by Stoneman's 16,000 Union troops. They were sent north to a prisoner-of-war camp at Camp Chase, Ohio where they were eventually paroled and sent home by October of 1865.