James is NOT a grandson of Jacob & Susannah (Thomas) Holtzlaw, he is their son.

A search on Wikipedia re older women giving birth, revealed that a dozen or so have been fully documented, with the last one being 54 years old. Susannah (Thomas) Holtzclaw, at 52, fits easily within the profile, and should be considered the mother of James Holtsclaw/Holsclaw until evidence proves otherwise.