p.s. I confirmed they are brothers!!!!!!!!!

Saint Louis Directory 1865
Smithers, Isaiah P.(John A. Smithers & Bro.) ,
r. 113 Chesnut
Smithers, John A.(John A. Smithers A Bro.) ,
r. 48 s. 15th
Smithkrs John A. A Bro. (John A.Smithers,
and Isaiah P.Smithers, ), undertakers , 113
Chesnut