John Wesley Hurst was Janetta’s 2nd husband, her first being Jehu Mixon, born 1767 in Darlington County, SC, and died 10 Oct 1831, Darlington County. John W. and Janetta married about 1838 (I have not verified this).
John Wesley was born 1811 in Newman Swamp, SC, son of Jesse D. and Nancy (McLaurin) Hurst. Janetta died in 1871, burial place unknown (not verified). John next married Mary B. Windham, and they had three children. John died in 1876. Mary appears as a widow in the 1880 Census for Cypress TWP, Darlington County, SC, with four children: daughter Anna A., age 8; daughter Lottie D., age 5; son John W., age 4. Mary died 25 Oct 1908, burial place unknown.
Jesse was born 1793 in SC, son of Isaac Henry and Priscilla (Marle) Hurst (not verified).
Hope this gives a few leads to pursue. Good luck in your research.